Frequently Asked Questions

Ketamine was first developed as a powerful anesthetic and rapid pain reliever, but research in the last two decades indicates it may be the biggest breakthrough in depression treatment in some fifty years. Hundreds of clinics around the world are now administering ketamine through intravenous infusions, but this requires a series of infusions for success. KetaMD’s signature KetaMelts™ allow regular ketamine treatment without requiring intravenous infusions and in the comfort of your own home.

KetaMD is a HIPAA-compliant telemedicine platform that provides affordable and potentially life-changing at-home medical ketamine treatments. Prescribed by medical professionals and guided by registered nurses via our secure platform, KetaMD provides safe and effective at-home ketamine treatments for those who are suffering from anxiety, depression, PTSD, and other mental health challenges. Through KetaMD’s nationwide network of medical professionals, adults who have received a qualifying diagnosis from a licensed medical prescriber receive an at-home ketamine treatment plan.

Ketamine tackles stress, anxiety, depression, and mood disorders in a unique and dynamic way. Working as a NMDA antagonist, ketamine essentially “resets and refreshes” the nerves in the brain, supporting the growth of new neural pathways which optimize healthy brain function.

By calming the brain’s main excitatory neurotransmitter, glutamate, ketamine enhances mental clarity and reduces mental chatter, making it easier to deal with life’s challenges and cope with mental health issues. 

Ketamine taps into the “default mode network”, the part of the brain which becomes active when we are thinking, daydreaming, reflecting on the past, and thinking about the future. When overactive, this network can be associated with stress and negative thought patterns. This can make it harder for people to cope with unexpected challenges, tragedies, and difficult life events.

Ketamine works on an area in the default mode network called the lateral habenula, which is associated with negative emotions and stress. When the lateral habenula becomes overloaded, it goes into a state called “burst mode,” triggering despair and lack of pleasure. Ketamine quickly elevates mood by blocking this bursting activity. According to Molecular Psychiatry, “Ketamine has also been shown to reverse the dendritic atrophy caused by chronic unpredictable stress exposure.” In other words, ketamine literally refreshes the brain.

In the hours following a treatment, ketamine triggers both synaptogenesis and neurogenesis. Neurogenesis is the process by which new neurons are formed in the brain and synaptogenesis is the formation of synapses between neurons in the nervous system. We refer to this phenomenon as “ketagenesis.” 

In contrast with many conventional antidepressants and anti-anxiety medications, whose effects last only with the presence of the medication in your body, ketamine rewires the connections in your brain, giving you the opportunity to develop new, positive thought patterns and behaviors so the healing benefits last well beyond your treatment. This is why it has shown to be so effective in patients with treatment-resistant depression and trauma. 

Additionally, ketamine blocks pain receptors and reduces inflammation, assisting in its effectiveness at treating many types of mood disorders, depression, anxiety, PTSD, sleep problems, and pain.

Ketamine can be used to treat depression, treatment resistant depression, postpartum depression, acute PTSD, complex PTSD (CPTSD), comorbid PTSD, alcohol addiction, drug addiction, anxiety mood disorder, bipolar mood disorder, obsessive compulsive disorder, neuropathic pain, migraine headaches, fibromyalgia, burnout and more.

While the experience is different for every person, many describe it as the most peaceful experience of their lives. Most people feel fully immersed in the present moment, with a clear mind and deep relaxation. It is often described as a journey through one’s own mind, where you may encounter beautiful visuals and can access difficult areas of your life from a new angle. 

The majority of people say they are simultaneously fully aware and fully enveloped in the experience. You may have the sensation of floating outside your body, leaving your habitual state of mind behind, and opening yourself to new possibilities. After the treatment, you may feel calm and present, and should be able to resume normal activity within one hour. With each treatment, people widely report new levels of clarity, energy, joy, and peace, with increasing results in the following days and weeks.

No. Special K is a powder form of ketamine that is snorted nasally in high doses. Just as with any drug obtained from an unregulated source, Special K’s purity and safety profile is unclear as it can be mixed with other psychoactive or harmful substances. Additionally, some clinicians hypothesize that ketamine that is snorted has a more robust activation of endogenous opioid receptors found in the periaqueductal gray area, potentially triggering addictive responses or abuse. To receive a medical benefit from ketamine, it must be administered by clinicians in a safe and thoughtful way.

Ketamine’s most common use is as an anesthetic, for everyone from babies to horses. In fact, because it’s so safe, ketamine is one of the most common anesthetics in the world. However, due to ketamine’s dissociative properties, at a low dose, this compound has profound effects on the brain. This makes it an excellent treatment for depression, anxiety, PTSD, addiction, and more.

Obviously, ketamine is not used at horse tranquilizer levels for the kind of treatment we are providing at KetaMD.

Definitely. Maybe you’ve already heard of ketamine and are aware of some of the other uses for this medication. Rest assured that medical ketamine, when administered in low doses like the ones found in our KetaMelts™ and used correctly, is very safe. Our KetaMD Nurse Guides are there to monitor you during your treatment to help ensure you have the best experience possible.

No. At subanesthetic doses, ketamine is not considered a hallucinogenic. It is more accurately defined as a dissociative. Ketamine is also a psychedelic (substance capable of producing profound experiences of reality). A very high anesthetic dose puts you to sleep, but at low, subanesthetic doses, you enter a dreamlike state characterized by colorful visuals, a feeling of euphoria, and the ability to mentally examine any troubling subjects in your life from a new and expanded perspective.

It is important, however, to let us know if you’ve had any history of hallucinations, psychosis, or other psychotic disorders as ketamine treatment may not be appropriate for you.

No addiction issues have arisen in the many studies investigating ketamine for use in depression, and no issues have arisen in the many decades that ketamine has been used for anesthesia.

However, this question often stems from ketamine’s colorful past as a street drug, a.k.a. “Special K,” “Vitamin K,” or simply “K.” When people use drugs recreationally (i.e. unsupervised, high doses, frequent dosing, self-administered, and unmonitored) and when ketamine is administered nasally (which may activate endogenous opioid receptors with more potency), this increases the chance for abuse.

KetaMD’s protocol of proper dosing and monitoring further lowers the risk of habituation and problematic use, and increases the overall benefit of receiving the treatment.

Yes, it’s completely legal. Ketamine is FDA-approved as an anesthetic and is being used off-label to treat pain, depression, and a variety of other conditions.

In clinical trials since 2000, ketamine has shown improvement in 70-80% of patients who are treated for depression. In fact, The American Psychiatric Association (APA) reports “compelling evidence that the antidepressant effects of ketamine infusion are both rapid and robust.”

For the last two decades, researchers at Yale have led ketamine research for patients with severe depression who have not improved with standard antidepressant treatments. More than half of participants show a significant decrease in depression symptoms after just 24 hours. These are patients who felt no meaningful improvement on other antidepressant medications.

If you’re struggling with depression, we know how desperately you want relief. Our hope is that ketamine becomes the first treatment for depression, rather than a final solution after a series of failed treatments, side effects, and prolonged suffering.

We will go over a detailed breakdown of our pricing packages. One of our biggest goals is making sure that this revolutionary treatment is more affordable and accessible than ever before.

Your KetaMD doctor will discuss this with you in your initial consultation. You may start with one session to get a feel for the treatment. This session will cause a brain “refresh” (see How does ketamine work?) and many people notice immediate results. The protocol established for treatment-resistant depression at Yale University and in NIMH clinical trials is six sessions within two weeks, followed by a single booster treatment as often as needed (commonly up to six months). Again, your KetaMD doctor will recommend the best treatment protocol for you.

No. Although there is a risk of some minor side effects like nausea and dizziness, you will be prescribed an anti-nausea medication to decrease the likelihood of these side effects. Our at-home treatments, which are guided by nurses on a secure, easy-to-use platform, significantly lower the risk of side effects disrupting your experience.

Ketamine treatment is not ideal for those with uncontrolled high blood pressure (hypertension), unstable heart disease (arrhythmias, congestive heart failure, etc.), high eye pressure/glaucoma, and active psychosis or psychotic disorders (schizophrenia). Your KetaMD doctor will determine if ketamine is right for you. In addition, women who are pregnant or breastfeeding or women who may be pregnant should not receive ketamine treatment.

As of now, ketamine treatment is not covered by insurance due to its off-label nature. However, we are working hard to change this, working with groups like the Ketamine Task Force to increase opportunities for reimbursement, approval, and acces

KetaMD is in the process of establishing gold standard safety and efficacy protocols through an extended beta trial. Our nationwide network of certified Nurse Guides and prescribing medical professionals can’t wait to see you. Please sign up for our mailing list to be notified as soon as KetaMD’s service becomes available in your state.

Until KetaMD is available to the public, it is important to choose a ketamine treatment path that is guided by medical professionals and follows the highest standards for safety and best practices for efficacy. There are hundreds of ketamine clinics around the country. Do your research to make sure there is both a strong medical group behind the clinic and that the setting is peaceful and quiet for the ideal experience.

KetaMD’s founders also founded the 501c3 organization, The Ketamine Fund, which is dedicated to providing free ketamine treatments to those most in need. The Ketamine Fund has already donated more than 500 free treatments to veterans and is on a mission to reduce suicide rates among this vulnerable and valued population. Your donations support deserving veterans suffering from PTSD to finally get the relief they deserve.

KetaMD leadership take seriously our obligation to protect the medical data we collect. We have built and continue to maintain a robust, HIPAA compliant cyber security program to protect your medical data. This comprehensive program, built upon industry best practices such as NIST and CIS guidance, ensures your data is safe and secure.

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